PIPLARTINE AND PIPERINE: a review of their biological activities
Keywords:
Piper; alkaloids; amides; chemistry medicinal; parasitology; biological activity.Abstract
Piplatine and piperine amides are found in species belonging to the Piperaceae family. The plants of this family are widely used in parts of the Amazon region for the treatment of some diseases, in cooking and as ornamental plants. In this context, this bibliographic review of the above mentioned amides aimed to provide a collection of published data to guide new studies on the biological activities of these substances (of natural or synthetic origin). The bibliographic search was performed in the CAPES periodic portal, using the keywords “piplartine”, “piperine” and “activity”. The references used in this study were analyzed by selecting only peer-reviewed articles published between December 2013 and December 2018 (piplartine) and 2017-2018 (piperine). The review also summarizes the antileishmanial and antiplasmodial activities investigated with the substances (1993-2018). In the review, we did not point to data such as dose response curves, negative and positive controls. In this sense, the review highlights the biological activities, the test models and the results obtained with these substances, with emphasis on the most investigated activities. From this research, we conclude that piplartine and piperine have been extensively investigated. The biological activities described here may guide future research that will seek to relate the potential of these amides and their respective synthetic analogues to other biological activities. Indeed, compounds that have long been known and have not reached the status of evidence-based medicine require further analysis.
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2021-06-27
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Silva, M. A. da, DA SILVA, F. B. ., PASSARINI, G. M. ., FIALHO, S. N. ., DOS SANTOS, A. P. D. A. ., MARTINEZ, L. D. N., TELES, C. B. G., & KUEHN, C. C. (2021). PIPLARTINE AND PIPERINE: a review of their biological activities. South American Journal of Basic Education, Technical and Technological, 6(2), 818–858. Retrieved from https://periodicos.ufac.br/index.php/SAJEBTT/article/view/2774
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