COMPOSTOS BIOATIVOS NATURAIS: AGENTES PROMISSORES NA REDUÇÃO DO EXTRESSE OXIDATIVO E PROCESSOS INFLAMATÓRIOS

Autores

  • Rafaela da Silva Oliveira CENTRO UNIVERSITÁRIO LUTERANO DE JI-PARANÁ (CEULJI/ULBRA)
  • Claudia Perboni Lucas CENTRO UNIVERSITÁRIO LUTERANO DE JI-PARANÁ (CEULJI/ULBRA)
  • Gabrielli Antonucci CENTRO UNIVERSITÁRIO LUTERANO DE JI-PARANÁ (CEULJI/ULBRA)
  • Francisco Carlos da Silva CENTRO UNIVERSITÁRIO LUTERANO DE JI-PARANÁ (CEULJI/ULBRA)

Resumo

A quantidade excessiva de radicais livres no organismo pode desencadear um estresse oxidativo, que está relacionado a processos inflamatórios e diversas doenças degenerativas. Os compostos bioativos presentes nos vegetais podem reverter este processo, promovendo melhorias na qualidade de vida. Deste modo, esta revisão visa elucidar a ação dos compostos bioativos na redução do estresse oxidativo e nos processos inflamatórios. Para tanto, realizou-se uma pesquisa bibliográfica, através de consultas em bases de dados, utilizando descritores e critérios de inclusão e exclusão. Por meio de estudos, sabe-se que a produção de radicais livres pode ocorrer como um processo fisiológico natural ou podem ser produzidos atráves da alimentação, consumo de álcool, tabagismo etc. Para contrabalançar essa produção, o organismo possui um sistema antioxidante que pode interceptar radicais livres do metabolismo celular ou fontes exógenas. Além disso, alguns vegetais possuem compostos bioativos, especialmente compostos fenólicos, terpenóides e algumas vitaminas, que apresentam uma atividade antioxidante e antiinflamatória por meio de diversos mecanismos de ação, podendo, por exemplo, neutralizar os radicais, diminuindo o estresse oxidativo, ou até mesmo inibir a expressão de enzimas envolvidas na inflamação. Portanto, os compostos bioativos são agentes promissores para o tratamento de diversas doenças.

Biografia do Autor

Rafaela da Silva Oliveira, CENTRO UNIVERSITÁRIO LUTERANO DE JI-PARANÁ (CEULJI/ULBRA)

Técnica florestal pelo Instituto Federal de Educação, Ciências e Tecnologia de Rondônia, com estágio supervisionado no laboratório de Botânica e Ecologia Florestal do Câmpus Ji-Paraná. Graduanda em Ciências Biológicas pela Centro Universitário Luterano de Ji-Paraná- CEULJI/ULBRA

Francisco Carlos da Silva, CENTRO UNIVERSITÁRIO LUTERANO DE JI-PARANÁ (CEULJI/ULBRA)

Biólogo bacharel com ênfase em Ecologia, Licenciatura em biologia, Mestre em Genética e Toxicologia e Doutor em Biologia Celular e Molecular Aplicado a Saúde pela Universidade Luterana do Brasil. Professor Adjunto do Curso de Ciências Biológicas, Membro do Núcleo Docente Estruturante (NDE) e Conselho de Curso (CC) do Curso de Ciências Biológicas do Centro Universitário Luterano de Ji-Paraná - CEULJI/ULBRA. Tem experiência em Ecologia, Mutagênese, atuando principalmente na atividade toxicológica, genotóxica e mutagênica de produtos naturais com potencial farmacológico, estresse oxidativo e antioxidantes.

Referências

ALMASSY J. A. A. et al. Folhas de chá: plantas medicinais na terapêutica humana. Viçosa: UFV, p. 233, 2005

KONAN, N.A. et al. Acute, subacute toxicity and genotoxic effect of a hydroethanolic extract of the cashew (Anacardium occidentale L.). J Ethnopharmacol, v.110 (1), p. 30-8, 2007.

PATEL, M.; BESSONG, P.; LIU, H. Traditional medicines, HIV, and related infections: workshop 2C. Adv Dent Res, v.23, p. 159-64, 2011.

CLARDY, J.; WALSH, C. Lessons from natural molecules. Nature, v.432, p.829-837, 2004.

KOEHN, Frank E.; CARTER, Guy T. The evolving role of natural products in drug discovery. Nature reviews. Drug discovery, v. 4 (3), p. 206, 2005.

GULLO, V. P. et al. Drug Discovery from natural products. Journal of Industrial Microbiology and Biotechnology, v. 33, p.523-531, 2006.

COSTA, L. S. da et al. Antiproliferative activity, antioxidant capacity and chemical composition of extracts from the leaves and stem of Chresta sphaerocephala. Revista Brasileira de Farmacognosia, v. 25 (4), p. 369-374, 2015.

MA, Q. et al. Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro. Revista Brasileira de Farmacognosia, v. 26 (6), p. 710-713, 2016.

JAYATHILAKE, C.; RIZLIYA, V.; LIYANAGE, R. Antioxidant and free radical scavenging capacity of extensively used medicinal plants in Sri Lanka. Procedia Food Science, v. 6, p. 123-126, 2016.

CARVALHO P.G.B et al. Hortaliças como alimentos funcionais. Horticultura Brasileira, v. 24, p. 397-404, 2006.

MANACH, C. et al. Polyphenols: food sources and bioavailability. The American journal of clinical nutrition, v. 79 (5), p. 727-747, 2004.

DELBONE, C. A. C.; LANDO, R. L. Importância ecológica e evolutiva dos principais grupos de metabólitos secundários nas espécies vegetais. In: Congresso de Educação do Norte Pioneiro. 10ª edição. UENP-CCNE-CLA-Campus Jacarezinho, p. 396-404, 2010.

PEREIRA, R. J., CARDOSO, M.G. Metabólitos secundários vegetais e benefícios antioxidantes. Journal of biotechnology and biodiversity, v. 3 (4), p. 146-152, 2012.

YAHIA, E. M.; GUTIÉRREZ-OROZCO, F. ; ARVIZU-DE LEON, C. Phytochemical and antioxidant characterization of mamey (Pouteria sapota Jacq. HE Moore & Stearn) fruit. Food Research International, v. 44 (7), p. 2175-2181, 2011.

CASTILHO, A. R; MURATA, R. M.; PARDI, V. Produtos Naturais em Odontologia. Revista Saúde-UNG, v. 1 (1), p. 11-19, 2007.

LISBOA, P.L.B et al. 2002. O estilo amazônico de sobreviver: manejo dos recursos naturais. In: LISBOA, P.L.B et al. Natureza, homem e manejo de recursos naturais na região de Caxiuanã, Melgaço, Pará. Ed.: Museu Paraense Emilio Goeldi.

SILVA, F. C. et al. Antigenotoxic effect of acute, subacute and chronic treatments with Amazonian camu–camu (Myrciaria dubia) juice on mice blood cells. Food and chemical toxicology, v. 50 (7), p. 2275-2281, 2012.

WATY, D. R.; SAPUTRI, F. C.; MUN’IM, A. Secondary Metabolites Screening and Acute Toxicity Test of Peperomia pellucida (L.) Kunth Methanolic Extracts. International Journal of PharmTech Research, v. 10 (1), p. 31-38, 2017.

KUMAR, S.; PANDEY, A. K. Free Radicals: Health Implications and their Mitigation by Herbals. British Journal of Medicine and Medical Research, v. 7 (6), p. 438-457, 2015.

REUTER, S. et al. Oxidative stress, inflammation, and cancer: how are they linked?. Free Radical Biology and Medicine, v. 49 (11), p. 1603-1616, 2010.

BARBOSA, K. B. F. et al. Estresse oxidativo: conceito, implicações e fatores modulatórios. Revista de Nutrição, v. 23, p. 629–643, 2010.

FRANSEN, M. et al. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1822 (9), p. 1363-1373, 2012.

TURCATEL, E.; FUNCHAL, C. S.; GOMEZ, R. Alterações Comportamentais e de Estresse Oxidativo no Sistema Nervoso Central pelo Uso de Álcool e Tabaco. Rev Neurocienc, v. 20 (3), p.444-454, 2017.

DE SOUZA, Eliziete Pereira; DA SILVA, Ivandro de França; FERREIRA, Leonardo Elias. Mecanismos de tolerância a estresses por metais pesados em plantas. Current Agricultural Science and Technology, v. 17 (2), 2011.

RAHAL, A. et al. Oxidative stress, prooxidants, and antioxidants: the interplay. BioMed Research International, p. 1-19, 2014.

ANGELIS, N. et al. Airway inflammation in chronic obstructive pulmonary disease. Journal of Thoracic Disease. v.6 (1), p.167-172, 2014.

PASCUAL, M. et al. Neuroimmune activation and myelin changes in adolescent rats exposed to high-dose alcohol and associated cognitive dysfunction: a review with reference to human adolescent drinking. Alcohol and Alcoholism, v. 49 (2), p. 187-192, 2013.

OLIVEIRA, G. B. et al. Minocycline mitigates motor impairments and cortical neuronal loss induced by focal ischemia in rats chronically exposed to ethanol during adolescence. brain research, v. 1561, p. 23-34, 2014.

TEIXEIRA, F. B. et al. Chronic ethanol exposure during adolescence in rats induces motor impairments and cerebral cortex damage associated with oxidative stress. PloS one, v. 9 (6), p. e101074, 2014.

LEE, H. et al. Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts. Toxicology letters, v. 240 (1), p. 140-148, 2016.

LERNER, C. A. et al. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PloS one, v. 10 (2), p. e0116732, 2015.

TSENG, B. P. et al. Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation. Antioxidants & redox signaling, v. 20 (9), p. 1410-1422, 2014.

LEITE, A.; SILVA, R.; CUNHA, E. Aplicação de um caso prático de doenças profissionais: relevância médico-legal metais pesados e carcinogénese. Arquivos de Medicina, v. 29 (4), p. 93-97, 2015.

LAGUERRE, M.; LECOMTE, J.; VILLENEUVE, P. Evaluation of the ability of antioxidants to counteract lipid oxidation: Existing methods, new trends and challenges. Progress in lipid research, v. 46 (5), p. 244-282, 2007.

BARREIROS, A. L. B. S.; DAVID, J. M.; DAVID, J. P. L. Estresse oxidativo: relação entre geração de espécies reativas e defesa do organismo. Quim. Nova, Vol. 29 (1), 113-123, 2006.

UDENSI, U. K.; TCHOUNWOU, P. B. Dual effect of oxidative stress on leukemia cancer induction and treatment. Journal of Experimental & Clinical Cancer Research, v. 33 (1), p. 106, 2014.

MOLLER, P. et al. Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles. Mutation Research/Reviews in Mutation Research, v. 762, p. 133-166, 2014.

WOHLGEMUTH, S. E.; CALVANI, R.; MARZETTI, E. The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology. Journal of molecular and cellular cardiology, v. 71, p. 62-70, 2014.

STORZ, P. Oxidative stress in cancer. In: Oxidative Stress and Redox Regulation. Springer Netherlands, p. 427-447, 2013.

FERREIRA, I. et al. Antioxidants in wild mushrooms. Current Medicinal Chemistry, v. 16 (12), p. 1543-1560, 2009.

BASTOS, D. H. M et al. Mecanismos de ação de compostos bioativos dos alimentos no contexto de processos inflamatórios relacionados à obesidade. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53 (5), p. 646-656, 2009.

WU, X.; ZHOU, Q.; XU, K. Are isothiocyanates potential anti-cancer drugs?. Acta Pharmacologica Sinica, v. 30 (5), p. 501, 2009.

FINLEY, J. W. et al. Antioxidants in foods: state of the science important to the food industry. Journal of Agricultural and Food Chemistry, v. 59 (13), p. 6837-6846, 2011.

AMAROWICZ, R. et al. Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies. Food chemistry, v. 84 (4) p. 551-562, 2004.

ANJO, D. L. C. Alimentos funcionais em angiologia e cirurgia vascular. Jornal Vascular Brasileiro, v. 3 (2), p. 145 - 154, 2004.

GARCÍA R. A. et al. Guayusa (Ilex guayusa L.) new tea: phenolic and carotenoid composition and antioxidant capacity. Journal of the Science of Food and Agriculture, v. 97, p. 3929–3936, 2017.

DEGASPARI, C.H.; WASZCZYNSKYJ, N. Propriedades Antioxidantes de compostos fenólicos. Visão Acadêmica, Curitiba, v. 5 (1), p.33-40, 2004.

VIGNOLI, J. A.; BASSOLI, D. G.; BENASSI, M. T. Antioxidant activity, polyphenols, caffeine and melanoidins in soluble coffee: the influence of processing conditions and raw material. Food Chemistry, Oxford, v. 124 (3), p. 863-868, 2011.

AMER, M. G.; MAZEN, N. F.; MOHAMED, A. M. Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study. International Journal of Immunopathology and Pharmacology, v. 30 (1), p. 13-24, 2017.

BERNOTTI, Sandra et al. Inflammatory reaction without endogenous antioxidant response in Caco-2 cells exposed to iron/ascorbate-mediated lipid peroxidation. American Journal of Physiology-Gastrointestinal and Liver Physiology, v. 285 (5), p. G898-G906, 2003.

Lee, K. W. et al. Vitamin C and cancer chemoprevention: reappraisal. Am. J. Clin. Nutr., v. 78, p. 1074-1078. 2003

RIZVI, S. et al. The role of vitamin E in human health and some diseases. Sultan Qaboos University Medical Journal, v. 14 (2), p. e157, 2014.

WARNER, K.; NEFF, W. E.; ELLER, F. J. Enhancing quality and oxidative stability of aged fried food with γ-tocopherol. Journal of agricultural and food chemistry, v. 51 (3), p. 623-627, 2003.

AMES, B. N. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, v. 475 (1), p. 7-20, 2001.

NWOSE, E.U. et al. The vitamin E regeneration system (VERS) and an algorithm to justify antioxidant supplementation in diabetes – A hypothesis. Medical Hypothe-ses, v. 70, p. 1002-1008, 2008.

YAMAGUCHI, K. K. L. et al. HPLC-DAD profile of phenolic compounds, cytotoxicity, antioxidant and anti-inflammatory activities of the amazon fruit Caryocar villosum. Química Nova, v. 40 (5), p. 483-490, 2017.

SOARES, E. R. et al. Compostos bioativos em alimentos, estresse oxidativo e inflamação: uma visão molecular da nutrição. Revista Hospital Universitário Pedro Ernesto, v. 14 (3), 2015.

ROBBESYN, F.; SALVAYRE, R.; NEGRE-SALVAYRE, A. Dual role of oxidized LDL on the NF-kappaB signaling pathway. Free radical research, v. 38 (6), p. 541-551, 2004.

AGGARWAL, B. et al. Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical pharmacology, v. 71(10), p. 1397-1421, 2006.

FITZGERALD, G. A.; PATRONO, C. The coxibs, selective inhibitors of cyclooxygenase-2. New England Journal of Medicine, v. 345 (6), p. 433-442, 2001.

HARRIS, R. C.; BREYER, M. D. Physiological regulation of cyclooxygenase-2 in the kidney. American Journal of Physiology-Renal Physiology, v. 281 (1), p. F1-F11, 2001.

RIBEIRO, R. A. et al.Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. The Journal of Urology, v. 167 (5), p. 2229-34, 2002.

BAUD, V.; KARIN, M. Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nature reviews Drug discovery, v. 8 (1), p. 33-40, 2009.

MARTINDALE, J. L.; HOLBROOK, N. J. Cellular response to oxidative stress: sgnaling for suicide and survival. Journal of Celluar Physiology, v.192, p.1-15, 2002.

WARBOYS, C. M. et al. The role of blood flow in determining the sites of atherosclerotic plaques. F1000 medicine reports, v. 3, 2011.

GOPALAKRISHNAN, A.; KONG, A. N. T. Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells. Food and Chemical Toxicology, v. 46 (4), p. 1257-1270, 2008.

SCAPAGNINI, G. et al. Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Molecular neurobiology, v. 44 (2), p. 192-201, 2011.

ZHANG, D. D.; HANNINK, M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Molecular and cellular biology, v. 23 (22), p. 8137-8151, 2003.

KENSLER, T. W.; WAKABAYASHI, N.; BISWAL, S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol., v. 47, p. 89-116, 2007.

KUMAR, A. et al. Resveratrol restores Nrf2 level and prevents ethanol-induced toxic effects in the cerebellum of a rodent model of fetal alcohol spectrum disorders. Molecular pharmacology, v. 80 (3), p. 446-457, 2011.

SOETIKNO, V. et al. Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2–keap1 pathway. Molecular nutrition & food research, v. 57 (9), p. 1649-1659, 2013.

VERAS, H. N. H et al. Topical antiinflammatory activity of essential oil of Lippia sidoides Cham: possible mechanism of action. Phytotherapy research, v. 27 (2), p. 179-185, 2013.

GUIMARÃES, A. G.; QUINTANS, J. S. S.; QUINTANS-JÚNIOR, L. J. Monoterpenes with Analgesic Activity-A Systematic Review. Phytotherapy Research, v. 27, p. 1-15, 2013.

ALMEIDA, J. G. L de. et al. Essential Oil Composition From Leaves and Fruits of Piper divaricatum G. Mey. Journal of Essential Oil Research, v. 21 (3), p. 228-230, 2009.

SILVA, J. A. et al. Antioxidant activity of Piper arboreum, Piper dilatatum, and Piper divaricatum. Revista Brasileira de Plantas Medicinais, v. 16 (3), p. 700-706, 2014.

SILVA, J. K. et al. Essential oil composition, antioxidant capacity and antifungal activity of Piper divaricatum. Natural product communications, v. 5 (3), p. 477-480, 2010.

BRITO, G.R. Atividade antinociceptiva e antiinflamatoria do citronelol em roedores. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Sergipe, Aracaju, 2013.

MCGUCKIN, M. A. et al. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflammatory bowel diseases, v. 15 (1), p. 100-113, 2009.

FERNANDES, E. S. et al. Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. British journal of pharmacology, v. 139 (5), p. 973-981, 2003.

TEIXEIRA, F. B. et al. Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats’ tongues. BMC Complementary and Alternative Medicine, v. 17 (1), p. 313, 2017.

GERTSCH, J. et al. Beta-caryophyllene is a dietary cannabinoid. Proceedings of the National Academy of Sciences, v. 105 (26) p. 9099-9104, 2008.

SAIN, S. et al. Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, v. 13 (1), p. 45-55, 2014.

LUCCA, L. G. et al. Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne). AAPS PharmSciTech, p. 1-9, 2017.

PASSOS, G. F. et al. Kinin B1 receptor up-regulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx. The Journal of Immunology, v. 172 (3), p. 1839-1847, 2004.

MEDEIROS, R. et al. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. British journal of pharmacology, v. 151 (5), p. 618-627, 2007.

BENTO, A. F. et al. β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. The American journal of pathology, v. 178 (3), p. 1153-1166, 2011.

VARGA, Z. V. et al. β‐Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice. British journal of pharmacology, 2017.

STORR, M. A. et al. Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. Inflammatory bowel diseases, v. 15 (11), p. 1678-1685, 2009.

CORREA, F. et al. Activation of cannabinoid CB2 receptor negatively regulates IL‐12p40 production in murine macrophages: role of IL‐10 and ERK1/2 kinase signaling. British journal of pharmacology, v. 145 (4), p. 441-448, 2005.

LIU, J. et al. Activation and binding of peroxisome proliferator-activated receptor γ by synthetic cannabinoid ajulemic acid. Molecular Pharmacology, v. 63 (5), p. 983-992, 2003.

O’SULLIVAN, S. E. et al. Novel time-dependent vascular actions of Δ 9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma. Biochemical and biophysical research communications, v. 337 (3), p. 824-831, 2005.

ROUSSEAUX, C. et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ. Journal of Experimental Medicine, v. 201 (8), p. 1205-1215, 2005.

SCHAEFER, K. L. et al. Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator‐activated receptor‐γ ligands on t helper type 1 chemokine regulation include nontranscriptional control mechanisms. Inflammatory bowel diseases, v. 11, n. 3, p. 244-252, 2005.

RIZZO, G.; FIORUCCI, S. PPARs and other nuclear receptors in inflammation. Current opinion in pharmacology, v. 6 (4), p. 421-427, 2006.

WAHLI, W. A gut feeling of the PXR, PPAR and NF‐κB connection. Journal of internal medicine, v. 263 (6), p. 613-619, 2008.

KIMBALL, E. S. et al. Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium‐induced colitis in mice. Neurogastroenterology & Motility, v. 16 (6), p. 811-818, 2004.

RAMAKERS, J. D. et al. The PPARγ agonist rosiglitazone impairs colonic inflammation in mice with experimental colitis. Journal of clinical immunology, v. 27 (3), p. 275-283, 2007.

SAUBERMANN, L. J. et al. Peroxisome proliferator‐activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis. Inflammatory bowel diseases, v. 8 (5), p. 330-339, 2002.

LU, T. et al. Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. Journal of Pharmacology and Experimental Therapeutics, v. 319 (1), p. 269-276, 2006.

BASTOS, D. H. M et al. Mecanismos de ação de compostos bioativos dos alimentos no contexto de processos inflamatórios relacionados à obesidade. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 53 (5), p. 646-656, 2009.

EVANS, D. A.; HIRSCH, J. B.; DUSHENKOV, S. Phenolics, inflammation and nutrigenomics. Journal of the Science of Food and Agriculture, v. 86 (15), p. 2503-2509, 2006.

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2018-10-09

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Oliveira, R. da S., Lucas, C. P., Antonucci, G., & da Silva, F. C. (2018). COMPOSTOS BIOATIVOS NATURAIS: AGENTES PROMISSORES NA REDUÇÃO DO EXTRESSE OXIDATIVO E PROCESSOS INFLAMATÓRIOS. South American Journal of Basic Education, Technical and Technological, 5(2). Recuperado de https://periodicos.ufac.br/index.php/SAJEBTT/article/view/1643

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